Understanding sex as a biological variable (SABV) is now considered one of the top priorities of the National Institutes of Health, spanning all institutes. This is because for most of clinical genetics, only one sex was studied, and now drugs, treatments, and therapies are failing at higher proportions in the unstudied (or understudied) sex, typically women. Layering on top of this, is the recognition that sex chromosomes, reproductive hormones, and gender identity all play unique rolls in both how disease manifests, and how patients are treated. I will talk about sex and ender in human health. Melissa Wilson, Phd talks about sex and gender in human health.